Project team

Optical Development

The team is responsible for the realization and subsequently characterization of the ESO-SIM (Ergodic Stochastic Ophthalmoscopic Structured Illumination Microscopy) fundus camera, starting from a previous version of the ophtalmoscope, already realized in the CLN2S – D-Tails Joint Lab. A Motorized Biological Model Eye (M-BIME) will be realized to initially test the super resolution ophthalmoscope prior to industrialization. Moreover, the characterization in both the fluorescent and the reflectance configurations will be performed, in order to explore and implement all the possible applications of the ESO-SIM device. The final objectives will be to engineer and realize the ESO-SIM module to be integrated in the commercial devices, and to test the device in operative conditions.

Marco Leonetti

Lead Researcher

Valentina Capalbo

Post Doc

Pier Paolo Palma

Researcher

Ojus Bagal

Researcher

Optical Development

Biochemistry

The Biochemistry team is tasked with formulating the delivery method for the specific TAU protein ligand BT1 (patent filed) through encapsulation in ferritin-based nanocages, appropriately modified and functionalized. Thanks to the collaboration with the Molecular Neuroscience group, the effectiveness of the delivery will be assessed in in retinal and brain organoids derived from both wild-type (WT) and Alzheimer's Disease (AD) induced pluripotent stem cells (iPSCs), as well as in AD mouse models and control (WT) mice.

Alberto Boffi

Full Professor

Paola Baiocco

Associate Professor

Lorenzo Barolo

Post Doc

Roberta Piacentini

Post Doc

Giovanna Cimaglia

PhD student

Biochemistry

Lab Testing

The team directed by Silvia Di Angelantonio is involved in the understanding of BT1 delivery and its impact on tau pathology in AD-related models, both in vitro and in vivo. To establish relevant cellular models, retinal and brain organoids will be realized from both wild-type (WT) and Alzheimer's Disease (AD) induced pluripotent stem cells (iPSCs). Afterwards, in vivo testing will be performed by intranasal administration in AD mouse models and control (WT) mice.

Silvia Di Angelantonio

Associate Professor

Chiara D'Antoni

Post Doc

Ylenia Gigante

Senior Technician

Anna Mirone

PhD student

Lorenza Mautone

PhD student

Lab Testing